🌍 It is estimated that 2/3 of all chronic diseases are caused by environmental and lifestyle risk factors.🌍 Leading environmental risk factors for global death/disease are air pollution, hot/cold temperature, lead and unsafe water.🌍 The exposome concept describes the health impact by all environmental and lifestyle risk factors over entire life course.🌍 It also considers… Continue reading Cardiovascular risk posed by the exposome

🐭👥 A combined mouse and human study by MARKOPOLO researchers from Mainz (University Medical Center, Max Planck Institute for Chemistry and Cyprus Institute) shows that shortterm exposure to synthetic nanoparticles (<250 nm) causes damage in remote organs, endothelial dysfunction and increased blood pressure, whereas microparticles (2-4 µm) accumulate in the lung leading to local pulmonary… Continue reading Differential inflammation, oxidative stress and cardiovascular damage markers of nano- and micro-particle exposure in mice: Implications for human disease burden

💡 Hypertension is multifactorial. It results from a complex interplay of biological, genetic, and environmental factors.💡 Environmental stressors play a major role – air, noise, and chemical pollution, built environments, and food systems significantly influence blood pressure levels.💡The “mosaic model”, a conceptual framework, explains hypertension and views it as a network of interconnected causes rather… Continue reading Environmental Hypertensionology and the Mosaic Theory of Hypertension

🔬 Healthy soil and clean water are essential to ecosystem sustainability and human well-being.🔬 Chemical pollution accounts for millions of premature deaths and non-communicable diseases, particularly CVD.🔬 Toxic chemicals cause cellular damage through oxidative stress, inflammation, and hormonal imbalances.🔬 Micro/nanoplastics, pervasive environmental contaminants, cause vascular injury, and transgenerational reproductive effects.🔬 Enhanced pollution controls and sustainable… Continue reading The links between soil and water pollution and cardiovascular disease

💡 Transportation noise causes neurohormonal activation, sleep impairment and stress responses.💡 Noise-induced stress hormone signaling via RAAS leads to inflammation, oxidative stress and cardiovascular dysfunction.💡 Noise increases the risk of diabetes and other cardiometabolic diseases.💡 Co-exposure to noise, air pollution or lack of green space causes cumulative increase of risk for diabetes.