⏰ Circadian rhythms influence cardiovascular function and disease progression, shaping daily patterns in events like myocardial infarction, heart failure, and arrhythmias.🧠 Autonomic balance shifts over 24 hours, with parasympathetic dominance during sleep and sympathetic activation during the day, affecting cardiac recovery and stress response.🩺 Despite dampened rhythms in heart failure, circadian cycles remain present –… Continue reading Circadian rhythms in cardiovascular disease

A commentary related to MARKOPOLO.

A commentary on physical activity and air pollution.

🫀 Environmental exposures like noise and air pollution are significant, modifiable risk factors for cardiovascular disease (CVD), acting alongside classic and behavioral risk factors such as hypertension, smoking, and diet. 🫀 Both noise and air pollution induce oxidative stress and inflammation, with noise primarily affecting the brain and stress axis, while air pollution damages the… Continue reading Impact of noise and air pollution on the cardiovascular system through the brain-heart axis

🌍 It is estimated that 2/3 of all chronic diseases are caused by environmental and lifestyle risk factors.🌍 Leading environmental risk factors for global death/disease are air pollution, hot/cold temperature, lead and unsafe water.🌍 The exposome concept describes the health impact by all environmental and lifestyle risk factors over entire life course.🌍 It also considers… Continue reading Cardiovascular risk posed by the exposome

🐭👥 A combined mouse and human study by MARKOPOLO researchers from Mainz (University Medical Center, Max Planck Institute for Chemistry and Cyprus Institute) shows that shortterm exposure to synthetic nanoparticles (<250 nm) causes damage in remote organs, endothelial dysfunction and increased blood pressure, whereas microparticles (2-4 µm) accumulate in the lung leading to local pulmonary… Continue reading Differential inflammation, oxidative stress and cardiovascular damage markers of nano- and micro-particle exposure in mice: Implications for human disease burden

💡 Hypertension is multifactorial. It results from a complex interplay of biological, genetic, and environmental factors.💡 Environmental stressors play a major role – air, noise, and chemical pollution, built environments, and food systems significantly influence blood pressure levels.💡The “mosaic model”, a conceptual framework, explains hypertension and views it as a network of interconnected causes rather… Continue reading Environmental Hypertensionology and the Mosaic Theory of Hypertension

🔬 Healthy soil and clean water are essential to ecosystem sustainability and human well-being.🔬 Chemical pollution accounts for millions of premature deaths and non-communicable diseases, particularly CVD.🔬 Toxic chemicals cause cellular damage through oxidative stress, inflammation, and hormonal imbalances.🔬 Micro/nanoplastics, pervasive environmental contaminants, cause vascular injury, and transgenerational reproductive effects.🔬 Enhanced pollution controls and sustainable… Continue reading The links between soil and water pollution and cardiovascular disease

💡 Transportation noise causes neurohormonal activation, sleep impairment and stress responses.💡 Noise-induced stress hormone signaling via RAAS leads to inflammation, oxidative stress and cardiovascular dysfunction.💡 Noise increases the risk of diabetes and other cardiometabolic diseases.💡 Co-exposure to noise, air pollution or lack of green space causes cumulative increase of risk for diabetes.